Garlic with Plavix - Free Essay Sample

Introduction

Pharmacodynamics can be studied at different levels depending on the drug or herbal's action in the body of a human being or any organism. The act of many medications in the body is dependent on chemical properties. For instance, garlic raises bleeding chances when consumed with other drugs or even with herbs with similar chemical properties. Patients scheduled to undergo surgery of any nature should not consume these supplements for about two weeks before the surgery's exact date. Platelet aggregation is one of the leading causes of heart disease. Plavix treats stroke, blood clots, or if there is a severe heart problem. The effectiveness of Plavix is a result of the antiplatelet activity. At recommended doses, Plavix forms one of the less active metabolites hence reducing its effects on patient's platelets. Moreover, tests show patients with poor CYP2C19 metabolizers.

Is your time best spent reading someone else’s essay? Get a 100% original essay FROM A CERTIFIED WRITER!

Order now

Myocardial Infarction Rate

Plavix reduces myocardial infarction rate and stroke in patients who experience moderate STEM and can manage medically. Plavix use with garlic is associated with an increase in blood clotting time.CYP2C19 metabolizes clopidogrel to its active metabolite. Besides, it inhibits this enzyme's action and activities, thus reducing plasma clopidogrel concentration and platelet inhibition. Coad ministration of garlic and Plavix raises the risk of gastrointestinal bleeding. In a day, the administration of 75mg may not modify the CYP2C9 substrate's pharmacokinetics in patients who receive an elongated warfarin therapy. The administration of Plavix with warfarin raises the rate of bleeding because it is independent of homeostasis. At a very high concentration of Plavix, clopidogrel inhibits CYP2C9.

Vascular Endothelium

Vascular endothelium secretes platelets inhibitors like nitric oxide, adenosine diphosphatase, and prostacyclin. Once this endometrium is damaged, there is the exposure of sub-endothelial compounds, which causes activation and aggregation of platelets. Treatment that inhibits aggregation of platelets reduces the risk of thrombosis hence helps in controlling cardiovascular infections. Due to high cost, the current and modern drugs that can prevent cardiovascular disease have to leave people with only one alternative to using herbal medicine. Garlic, on the other hand, is an herbal medicine that is very common all over the world.

Moreover, many and significant concerns have been put in place over recent years to identify and explain garlic's role in preventing heart diseases. Besides, few statistical and scientific data can clearly show that this product's medicinal and therapeutic properties do not exist. Although there are no scientific data to explain the medicinal value of garlic, studies carried out to know the role of garlic in preventing cardiovascular disease. Moreover, the consumption of garlic functions as an antithrombotic agent and helps prevent platelet aggregation. Furthermore, garlic is incorporated in diet to accelerate wounds' healing and boost the immunity system as an anti-oxidant and antibiotics agent.

Therapeutic Effects

Garlic therapeutic effects connect to their organosulfur compounds like cysteinesgamaglutamil and cysteine sulfoxides. Other significant and beneficial components primarily found in garlic are methyl ajoene, diallyl trisulfide, and diallyl disulfide. Studies undertaken about these compounds showed that DADS and DAT could maximize the aggregation of platelets in the availability of other factors like oxidative agents and ADP. Extraction of the gastric prevents the formation of thromboxane hence preventing clumping together of platelets. Moreover, other compounds extracted from these plants, like quercetin and chromogenic have been proved to contain inhibitory effects that affect platelet aggregation.

People who take Plavix are not supposed to take omeprazole or garlic because the combination of these two supplements has dangerous outcomes. Plavix for people who have heart diseases reduces the risk of other attacks brought about by blood clotting. Besides, in the stomach, the drug can be so hard and, as a result, cause gastrointestinal bleeding; therefore, most people are prescribed for a PPI treatment to reduce the content of acids. A combination of omeprazole and Plavix minimizes the level of effectiveness of drugs because they usually block enzyme CYP2C19. Moreover, other drugs like fluconazole, felbamate, ketoconazole, voriconazole, and etravirine block enzyme CYP2C19. Garlic can potentiate the advanced effects of anticoagulants, thrombotic agents, and other inhibitors, raising the chances of bleeding for long without clotting. Some isolated reports of complications resulting from bleeding are associated with high dietary intake of garlic and decreased INR.

Consultation of health care is right before the consumption of herbal or any alternative medicine. Generally, taking more quantities of garlic and garlic supplements should be avoided when one is using coagulation agents. All patients should be advised to quickly report any bleeding sign to their respective doctors, including headache, swelling, dizziness, prolonged bleeding, raise in menstrual flow, and nosebleeds.

Conclusion

Supplements affect medicines' actions or how our bodies absorb, utilize, or even eliminate it. For instance, the accessory can influence various medications like serotonin, increasing the body's level. Continuous use of such medicines leads to drug nutrients depletion, affecting the body's ability to maintain the nutrient level required in the body. Moreover, consuming the high content of vitamin k makes warfarin not to function correctly. One the other hand, food rich in tyramine can lead to very high blood pressure, especially to people who take monoamine oxidase inhibitors. Some people rely on garlic to control colon cancer and prostate cancer. Despite this impotent use, one must be keen on which other medicines and supplements to combine.